skin-aging model, in which aging was caused by repetitive ultraviolet B (UV-B) irradiation. Physiological analysis of the skin surface following repetitive UV-B irradiation of 8 weeks revealed inhibition of erythema levels and reduction of tran-
نویسندگان
چکیده
The skin anti-aging effects of orally administered salmon nasal cartilage extract (SNCE), which includes abundant proteoglycan, were investigated using a hairless mouse skin-aging model, in which aging was caused by repetitive ultraviolet B (UV-B) irradiation. Physiological analysis of the skin surface following repetitive UV-B irradiation of 8 weeks revealed inhibition of erythema levels and reduction of transepidermal water loss (TEWL) due to oral administration of SNCE. Similarly, inhibitory actions of epidermal and dermal hypertrophy were revealed by hematoxylin and eosin staining. Furthermore, effects on the hydration level of the skin surface by SNCE administration were indicated at 4 weeks of UV-B irradiation, but greater effects were not apparent. These results indicate that SNCE may serve as an anti-aging agent for healthy skin.
منابع مشابه
Anti-aging effects of high molecular weight proteoglycan from salmon nasal cartilage in hairless mice.
Proteoglycans comprise a family of complex macromolecules consisting of a core protein with covalently attached glycosaminoglycan (GAG) chains. The skin anti-aging effects of oral administration of proteoglycan fractions with different molecular weights from salmon nasal cartilage were investigated in a hairless mouse model of skin aging; aging wa...
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